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First-in-human trial primes immune system to accept donor livers
UPMC and University of Pittsburgh clinician-scientists have weaned and kept multiple liver transplantation patients off of all immunosuppressant drugs for more than three years through a first-in-human clinical trial of a ...
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Large trial shows bone healing 'superpower' in children
Broken wrists are among the most common injuries in children, accounting for about half of children's fractures. Severely displaced distal radial fractures, where the bones move out of place, are often routinely treated with ...
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Medical research news
Fructose emerges as a key driver of metabolic disease
A new report, published in Nature Metabolism, is shedding light on the distinct and underappreciated role of fructose in driving disease, separate from its role as a simple source of calories.
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A major pregnancy scare collapses: Tylenol shows no autism risk in more than 1.5 million children
Acetaminophen, which also goes by names like paracetamol or Tylenol, is a common over-the-counter pain reliever and fever reducer. It is often prescribed during pregnancy to help with mild to moderate pain. Recently, there ...
Your phone already sees the warning signs: Sleep, movement and mood data can spot depression early
Depression is among the most widespread mental health disorders worldwide, affecting an estimated 1 in 20 people. It is characterized by persistent sadness, hopelessness, disrupted sleep patterns, changes in appetite and ...
The subtle science behind safer brain implants
In a recent publication appearing in Advanced Science, researchers at the Netherlands Institute for Neuroscience challenge the assumptions surrounding the design and materials used for brain implants. Softer, flexible implants ...
12 hours ago
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Menstrual cycle reshapes nearly 200 blood proteins, offering a broader view of women's health
It is a process as old as humanity itself, yet there is still much we do not know about women's menstrual cycle and the impact it has on the entire body. Now, a team of researchers from the Department of Clinical Medicine ...
12 hours ago
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High-precision human immune aging clock identifies RUNX1 as key target for T cell senescence
The immune system acts as a critical sentinel of organismal aging, integrating the sensing of physiological states with the execution of defense and clearance functions. Immunosenescence not only reflects systemic functional ...
12 hours ago
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Global trial shows novel treatment for triple-negative breast cancer nearly doubles survival
A global, multicenter phase III trial, TROPION-Breast02, led by a senior medical oncologist and researcher from the National Cancer Centre Singapore, has demonstrated a significant breakthrough in improving the survival of ...
14 hours ago
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Fat cells steer flies away from pathogen-tainted food through a newly revealed neural circuit
If humans or animals eat something that causes them to feel unwell, they subsequently avoid this food source. Until now, it has been unclear precisely how this avoidance learning takes place. A new study shows that communication ...
13 hours ago
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Programming the immune system to manufacture its own therapeutic proteins
An innovative gene-editing strategy could establish a new way for the body to manufacture therapeutic proteins—including certain kinds of highly potent antibodies that are naturally difficult to produce—by reprogramming the ...
16 hours ago
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First-of-its-kind drug aims to protect the heart while increasing effectiveness of cancer treatments
A team of University of Alberta researchers has developed a cardio-oncology drug that protects the heart from chemotherapy damage while enhancing the effectiveness of cancer treatments against tumor growth and spread. In ...
17 hours ago
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Chemical NDMA is much more likely to cause cancerous mutations after early-life exposure, study suggests
A new study from MIT suggests that a carcinogen that has been found in medications and in drinking water contaminated by chemical plants may have a much more severe impact on children than adults. In a study of mice, the ...
17 hours ago
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A black licorice compound slashes gut inflammation and cell death in IBD models and animals
A new study published in Stem Cell Reports demonstrates how a human stem cell-derived model of the intestine can be used to identify potential therapies for inflammatory bowel disease (IBD), highlighting glycyrrhizin as a ...
19 hours ago
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A two-way brain interface could help restore walking after paralysis by linking thoughts, robotic legs and sensation
Restoring both walking and sensation to patients with paraplegia is an ambitious goal—but a team of researchers from the Keck School of Medicine of USC, the University of California, Irvine (UCI) and the California Institute ...
18 hours ago
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These lab-grown insulin cells reverse diabetes in mice and clear a major hurdle for type 1 treatment
Researchers at Karolinska Institutet and KTH Royal Institute of Technology in Sweden have developed an improved method for creating insulin-producing cells from human stem cells. The results, published in Stem Cell Reports, ...
19 hours ago
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Biological shield can prevent skin cancer cells from transforming into aggressive metastatic forms
A new study has identified a molecular guardian that keeps skin cells from forgetting what they are and transforming into aggressive, migratory killers. By stabilizing a master genetic switch, this protein shield prevents ...
20 hours ago
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Beyond cell death: The hidden drivers of stem cell aging
As we age, our ability to maintain healthy blood and a strong immune system gradually declines, largely because hematopoietic stem cells (HSCs), the cells responsible for producing all blood cell types, begin to lose their ...
20 hours ago
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This shrimp-inspired camera sees hidden cancer spread and could transform how surgeons remove lymph nodes
Researchers have developed a compact camera that captures ultraviolet, near-infrared, and visible images using a single chip. Inspired by the multiwavelength vision capability of the mantis shrimp, the camera could help surgeons ...
20 hours ago
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Gut microbes reveal a surprising tie to cortisol spikes during acute stress
The gut microbiome influences numerous physiological processes. Researchers at the University of Vienna have now demonstrated for the first time that, in healthy adults, the diversity of gut bacteria and their capacity to ...
11 hours ago
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