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Common deworming drug helps restore lung cancer's sensitivity to targeted therapy in mice
A form of lung cancer, which is found in about 10%–15% of Western patients and 40%–50% of Asian patients, is driven by a mutation in the epidermal growth factor receptor (EGFR) gene. Gefitinib is a go-to drug that shuts down ...
6 hours ago
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A gut microbe makes a fatty acid that cuts artery plaque in half in mice
A common gut bacterium produces a molecule that slows cholesterol production in the liver. When researchers gave the molecule to mice prone to artery disease, the animals developed roughly half as much fatty plaque as untreated ...
14 hours ago
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Medical research news
Reversing age by reprogramming gene expression networks
Every organ and tissue progressively loses function and integrity as it ages. In fact, researchers have identified "hallmarks of aging" that not only present specific processes impacted by age, but are also thought of as ...
4 hours ago
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Reversible genetic switches could give cancer immunotherapy more precise control
A genetic switch that activates immune cells as they fight tumors: this is the new strategy developed by an international research team coordinated by Velia Siciliano at the Istituto Italiano di Tecnologia (IIT—Italian Institute ...
5 hours ago
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How RNA molecules influence the development of aggressive leukemia
Researchers at the University of Veterinary Medicine Vienna, in collaboration with the CeMM Research Center for Molecular Medicine and St. Anna Children's Cancer Research, have developed a new analytical method that reveals ...
1 hour ago
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AI misuse and nuclear famine could threaten humanity's survival before 2100
The fate of global health does not rest on any single disease. True preparedness means pairing the fight against illness with strength in finance, climate, defense and security. The COVID-19 pandemic, which brought the world ...
Common leukemia mutation derails protein positioning during cell division, study reveals
Experts from the University of Nottingham have discovered how a common genetic mutation disrupts the positioning of a key protein during cell division, revealing a new mechanism behind acute myeloid leukemia and a potential ...
3 hours ago
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Mixed beam measurement method could help make ion cancer therapy more precise
In ion beam therapy, atomic nuclei are accelerated to high energies in a particle accelerator, for example, a synchrotron, and precisely directed at a tumor. There, they damage cancer cells and destroy tumor tissue. This ...
2 hours ago
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Maternal vaccination helps protect newborns from deadly bacterial bloodstream infections, mouse study suggests
Researchers at Washington University School of Medicine in St. Louis found that a vaccine given to pregnant mice protected their newborn pups from a severe bloodstream infection caused by Klebsiella pneumoniae, a dangerous ...
7 hours ago
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What happens when brain tumors return? International study tracks genetic changes behind recurring cancers
When patients are diagnosed with certain brain tumors, one of the biggest unanswered questions is what happens when the cancer returns. Among those are IDH-mutant gliomas, a group of brain tumors that invariably recur despite ...
3 hours ago
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Skin measurements show link between insomnia and disrupted fear responses
A new computational model using skin conductance measurements to estimate stress-related emotional arousal found a significant difference in learned fear and safety responses over time between adults with and without insomnia.
7 hours ago
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Insights about cachexia, one of cancer's most common complications, hiding in routine patient data
Cancer cachexia has long been one of oncology's most stubborn unsolved problems. This severe, uncontrollable wasting affects roughly half of all cancer patients. It makes treatment harder to tolerate, erodes a person's quality ...
3 hours ago
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Commonly prescribed blood-pressure drug may stimulate 'healthy' brown fat
Scientists have discovered that the drug losartan, commonly prescribed for high blood pressure, boosts brown adipose tissue activity in mice, enhancing their metabolism. This indicates that repurposing losartan—an angiotensin ...
10 hours ago
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What if mosquito saliva holds the key to better fighting Zika, dengue and West Nile viruses?
Mosquitoes do more than simply transmit the viruses they carry: Their saliva may actively help these viruses establish infection in the body from the very moment of the bite. This is the finding of a study conducted by a ...
7 hours ago
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Trapping cancer-driving DNA rings outside cell nucleus silences their genes, researchers find
Cells from rapidly growing, highly metastatic tumors often contain numerous rings of extrachromosomal DNA (ecDNA). This circular DNA frequently carries oncogenes—genes that promote cancer. Researchers have long sought vulnerabilities ...
8 hours ago
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MRI analysis tool reveals brain artery differences missed by older software
The brain's network of blood vessels plays a critical role in maintaining neurological health. Changes to these vessels are associated with conditions including stroke, cognitive impairment and dementia. Yet studying the ...
2 hours ago
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Cancer-promoting protein also helps engineered immune cells fight tumors in lab tests
Colorectal cancer has become the leading cause of cancer-related death for people under 50. Its most common forms generally aren't treatable, either through conventional means like chemotherapy or newer immunotherapy drugs.
4 hours ago
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Deep brain stimulation study links multiple pathways to sustained improvement in treatment-resistant depression
Stimulation of specific brain connections was associated with sustained improvement in people receiving deep brain stimulation (DBS) for treatment-resistant depression, Mount Sinai researchers reported. The findings could ...
8 hours ago
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Molecular glue degraders show early promise in reducing Alzheimer's-linked brain plaques
A research team led by Indiana University School of Medicine scientists has discovered a new method for reducing the formation of amyloid plaques, which disrupt brain function in all aging adults but are particularly prevalent ...
9 hours ago
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Placental protein may offer clues to early brain development
The placenta, the temporary organ that forms during pregnancy to carry oxygen and nutrients from mother to baby, is vital to healthy gestation, yet it remains understudied. While its function and purpose are well established, ...
4 hours ago
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